I am interested in hearing from women who have never tried to get pregnant and therefore do not have any specific infertility issue per se, other than age. Mar 15, 2011 #2. It is used for low/poor responders -- often women with high FSH and/or over 35 years of age. Dont know what. We use cookies to improve your experience on this website and so that ads you see online can be tailored to your online browsing interests. I also did ganirelix during this time. Hello thanks for sharing. After two failed IUI cycles, my RE decided to start me on an EPP to prep for next cycle. Before starting the pills, we need to wait until you are in the correct stage of your menstrual cycle (the luteal phase). This time she is switching me to EPP w/ 100 Follistim/150 Menopur. Recent Topics Julie, will be KMFX for you and those embryos! BabyCenter may earn a commission from shopping links. Anyhow, do you know how what they wanted the priming to do? During cycle 1 you use OPKs to track your LH surge and ovulation. You may wonder how thats possible. Please specify a reason for deleting this reply from the community. Lupron when take in larger doses suppresses pituitary function, but when taken in smaller doses, it does the opposite. I would be doing a low stim protocol with estrogen priming. Thank you for subscribing to our newsletter! I am, Hi Ladies! The results are below and as you can see, success rates do seem to drop off after 300 IUs per day of gonadotropin. Hi there. No, IVF 5 was the estrogen priming. Spandorfer said it would not suppress me to much not sure about this, need to speak with him further. AMH 28. I did EPP my second round of IVF. President, ASRM That matters because if ovulation occurs before the retrieval, eggs cant be retrieved and the cycle will be canceled. Estrogen priming attempt #1, late December 2019: during the luteal phase of that now IUI cycle, I took oral estrogen. I'm starting with this IUI and then will see how I respond and move forward from there. Any 43+ Have Successful IVF with Own Egg? We're not even 100% sure we are staying with my current clinic but I wanted to research ahead of time either way. There are two downsides to this protocols: The long duration of injections (they start the previous cycle) and. it's 1 week since last patch. This is not recommended for shared computers. Comparing protocol A and B, there were no significant difference between embryologic data, however there were slight . Associate Director, REI Estrogen priming is pretty standard for over 40. From what I've seen on the boards, ladies get a higher number and higher quality. Thanks for sharing. I am only 28 with normal amh/fsh levels so we were pretty shocked and upset when we only had a couple embryos on day 3 and then nothing to freeze. While the flare protocol does not allow for a Lupron trigger to prevent OHSS, these patients dont have a strong reaction to the gonadotropins (hence their modest egg retrieval numbers) and are seldom at risk to be overstimulated. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are used to stimulate the ovaries to recruit and develop more than one follicle. February 7 - lost our little twin, Baby B had no heartbeat at 20 weeks, June 8, 2011 - DD was born healthy and her twin brother was born to Heaven. IVF Compared To Other Fertility Treatments, The Steps and Decisions In The IVF Process, Pregnancy Testing, Early Pregnancy and Delivery, The Impact of Donor Eggs, Donor Sperm or A Gestational Surrogate, The Impact of A Patients Condition or Diagnosis, Fertilization With Conventional Insemination vs. ICSI, Which Patients Benefit From Which Approach, Growing Embryos To Cleavage or Blastocyst Stage, Exceptions Where Cleavage Stage Makes Sense, PGT-A and PGS Genetic Screening of Embryos, Benefits of PGT-A (or PGS) Genetic Testing, The Negatives of PGT-A (or PGS) Genetic Screening. This was my worst cycle ever only yielding 2 retrieved follicles that did not fertilize. Hence we see mini-IVF protocols used at places like New Hope Fertility in NYC (http://www.newhopefertility.com/?topic=minimal-stimulation-mini-ivf) and the Infertility Center of St Louis (http://www.infertile.com/closlook/biograph.htm); and, Hello, Very helpful! I have AMH of 0.1 or something like that. After being on BCPs for so long, it took a long time for my period to come back (it's been 5 years though now), but my cycle has still never been the same so I'm wary of BCPs. Second, this study was only done in cycles using a fresh transfer. Estrogen is administered during the luteal phase of the previous menstrual cycle to "prime" the FSH receptors which enhances the response to FSH. I did EPP, using a climara patch every other day starting day 8 after ovulation until period came. DS was born June 22nd, 2007!!!!! This is caused by insufficient potassium reaching the fruit due to environmental factors such as high air/soil temperatures and overcast skies or heavy fruit load on plants with lower organic matter content in their soils. Johns Hopkins School of Medicine, Medical Director, REI Regular menstrual cycles between 21 and 40 days Presence of both ovaries Meets criteria for DOR by the recent ASRM/ACOG Committee Opinion antimllerian hormone (AMH) value less than 1 ng/mL antral follicle count less than 5-7 and follicle-stimulating hormone (FSH) greater than 10 IU/L or I am curious what anyone's experience has been with EPP. You can be assured it is a good protocol. Below is a meta-analysis of 17 (relatively small) studies that, taken together, show the strategies have nearly identical pregnancy rates. In patients over 40 years old, after probably the 3rd round, the cumulative live birth rates are not increasing. It was day 3 of my period. An analysis that combined six extremely small studies (that in aggregate only included about 160 patients) show gains in live birth rates, as you can see below. Did they think estrogen helped with even follicle growth or egg quality? After you go off BCP theyll do a baseline bloodwork and ultrasound to see what your levels are without having drugs in your system. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. What affect did the epp have on your follicles? I starts on day 1 of my cycle for 25-26 days of estrace.. Not sure why.. undefined will no longer be visible to you including posts, replies, and photos. It all depends on your tests and what specific information they have for you. Started doing the patches 10 days before my period was scheduled to start. Ultimately there are two protocol strategies doctors will use: either the Long Agonist or Antagonist protocols. This will be my first IVF round and I w, Hi All, Please whitelist our site to get all the best deals and offers from our partners. I just had my ER last week: stimmed for 13 days, started ganerilix on stim day 8, retreived 7 eggs, 3 were mature, 3 fertilized, 1 blastocyst was frozen today on day 5 and I have 2 morulas that will bhopefully be frozen tomorrow as long as they are blastocysts. Specifically, poor responders (a less than pleasant way of referring to women who produce few eggs per retrieval), do equally well taking 150 IUs of gonadotropin as 450 IUs. 14 retrieved, Trying concieve since 40 They put me on birth control pills for a month and are skipping the early stage Estrace this time around. I have AMH of 0.1 or something like that. I might have ovulated rather than had empty follicles. I am scheduled to take estrace 7 days after ovulation coming up (the cycle before) presumably for about 7 days until next cycle Not sure why you would do prometrium before you cycle? There is a ton of data out there for 'younger' women 35-42 with fertility issues but I'd like to be able to g, I was taking Estrace and Androderm patch when I went in for my base sonogram and they said I was already ovulating! Did not cover diagnostics like doppler test (40 copay but insurance might have covered this), communicable testing ($400 per person), and specialty meds . Implantation Calendar: What is Happening During the Two Week Wait. Weill Cornell Medical Center, Division Chief Please re-enable javascript to access full functionality. Hey Michelle, I haven't forgotten about you. Though I had 4 or 5 follicles to begin with, only ended up with one. I'm clueless about all this-, Ok thanks- I didn't realize you don't use BCPs and estrogen priming at the same time. Best of luck. Use of this site is subject to our terms of use and privacy policy. I never hoped so I never even asked that question. Confirms hormone levels are baseline and gets antral follicle count as a basis for cycle prognosis. BFP oct 16th!!! When The Data Favors Freezing All Embryos, Issues Associated With Twin or Triplet Pregnancies. FET October 6, 2010 - this is it I hope a tweak of the protocol will help or maybe it was just an off cycle for me. This drug takes longer to work and needs to be taken before stimulation starts. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. The hypothesis is that if we treat patients prior to starting their IVF cycle with estrogens ( the estrogen priming protocol) or androgens ( such as DHEA) , they will produce more eggs because more follicles will be recruited when we start the superovulation . You are posting as a Guest without being logged in. This protocol is used almost exclusively in women whove had a poor response in a previous cycle or who have evidence of diminished ovarian reserve (AMH less than 0.5 or an AFC less than 5). I'm struggling not to blame myself as my husband's swimmers are per. The Ukrainian Tribute Growout is a great opportunity for tomato lovers to get their hands on some unique and delicious varieties. maternal age" i.e. While gonadotropin is the critical drug in most every protocol, its not the only drug. Several functions may not work. The company offers Elephant Gigantes seeds, as well as free seeds that come with recommended shelf life information included. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. I tried it and it seemed to help with even follicle growth but so some reason I had less eggs in the follicles than prior cycle when I was on bcp first? Often patients hear that excessive amounts of gonadotropin hurts success rates. Estrogen priming refers to supplementing women with extra estrogen (estradiol) during the luteal phase - that's the last two weeks - of the prior menstrual cycle before beginning ovarian hyper-stimulation for IVF. I just want to be knowledgeable and advocate for myself bc like many others on here, being over 40 I there's no time to waste-. Similarly, when an investigator named Revelli decided to swap out a few days of gonadotropin for clomid in this poor responder population in Italy (and thereafter resumed gonadotropin at low levels), he saw similar rates of success to more conventional levels of gonadotropin use. There are a number of drugs that can be tacked onto the beginning of a cycle that may increase the odds of success. This clinic is more generous with freezing, so they tested and froze a few other blasts as well, which the other clinic would have thrown out. Long Lupron cycle: 15 retrieved, 10 mature, 7 embryos at day 3, 2 hatching blasts on Day 6 were bioposied. Please enable JavaScript in your browser to load the challenge. The answer lies in the drug the protocol uses to trigger the eggs to mature so that they can be retrieved. However, for poor responders many doctors worry such a long duration of suppression can hurt outcomes. My second included BCP before stimulating and I didnt stimulate well. Similarly, many doctors believe low dose approaches work equally well as high dose approaches on women who are likely to be hyper responders. These are women who have a high AMH or had a high number of eggs retrieved in a previous cycle. As a result, its hard to correct for confounders like the fact that harder cases may (or in our minds, probably) had been given more drug and so the underlying condition, rather than the dose taken, contributed to the lower rates of success. Some clinics use EPP more than others. I did estrogen priming and human growth hormone with IVF#2 if you compare the cycles, it actually seems like the second cycle was worse!! :) worked well for me. Im on this for 21 days starting on cycle day 1. After seven long years consumed by infertility I am finally moving forward, wishing my son was with me, but grateful for the two children I have here with me. I will be doing an FET in March/April, I started taking 4mg of estrace on cd 21. It's a horrifyingly traumatic experience. I hav, My last ivf cycle was cancelled/converted to IUI due to being over suppressed by birth control pills. The first question is naturally, which protocol is more likely to deliver a baby, and when investigators looked at the two most popular strategies, Long Agonist and Antagonist, it became clear both were equally effective in the general IVF population. Ganirelix is contraindicated in pregnancy. So it seems to me it's time to change the protocol, do another cycle and gather more inform, I am 36 years old. Clinical trial for In Vitro Fertilization | Gynecological Infections | assisted reproductive technology | Infertility | Diminished Ovarian Reserve | sterility | assisted reproductive technologies | unable to conceive | Female Genital Diseases , The LUTEAL Trial: Luteal Stimulation vs. Estrogen Priming Protocol I was on BCP for 20 years (have been off for several now) and it took me a long time to normalize after coming off them. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. I understand the idea for the patch is to help time the growth of follicles vs. increase the number? Does anyone have experience with this? It was my best in terms of numbers and success. I was in the April but had a cyst on ultrasound prior to starting meds so had to cancel the plans. This is done by administering estrogen, typically via an estrogen patch or an injection, sometimes along with additional Gonadotropin-releasing hormone. Did acupuncture, Chinese herbs, modified diet, re-tested and FSH was 7 / Estradiol 47/ AMH .4 Only 2 drugs during stim and finally got one good pgs tested embryo!!! We are going to bump up my gonal f too. I stimmed for 13 days. They studied what happens when you replace gonadotropin with clomid (a cheaper, less potent alternative) for a few days before the retrieval. So I think I was on estrogen for about a couple weeks then started stimming (antagonist protocol). My doc started me on estrogen patch, one patch changing every 3 days until my period for 5 days and I just took it off and will be takingClomiphene after a day of taking off the patch, then after a day start stim. First round I had few follicles 10 and scattered growth after taking bcp before cycles for about 13 days; Tried epp round after that, and had more synchronized growth with same number of follicles. FSH 7.7 ( done 1 year ago ) First round , on bcp for 2.5 weeks. 1) focus on the quality (not quantity) of eggs. A gonadotropin-releasing antagonist hormone (GnRH-ant) is used to stop the ovaries from releasing the matured eggs and allows time for additional maturation until eggs are retrieved for fertilization. Typically, you also add other stims once you start your cycle, too (Menopur, GonalF), so those could be in high doses. We ended up refinancing our home and getting help from family. Ramped up to cycle on BCP for two weeks and Lupron 10 units 2x/day on stims. On the other hand, the Long Agonist protocol cant use Lupron as the trigger because it already deploys Lupron elsewhere. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. To conclude, in the group of patients . Hi. Please re-enable javascript to access full functionality. However, that information will still be included in details such as numbers of replies. An FSH drop-down protocol is used to Gardening, outdoors, country living, my furbabies, my DH, anything but working! I don't know why they didn't take, but I still think it is a good one to try. By and large there are two easy ways to think about protocols: how much gonadotropin (the drug that prompts follicles to grow) gets used, and what other drugs get used alongside the gonadotropin which is typically what defines a given protocol strategy. You currently have javascript disabled. Get Ready for a New Season of Gardening -Choose from Tomatoes, Peaches, Corn, Zinnias & More! Transfer was canceled. How did it go with the EPP? . Take a look at the data below published on roughly 1,000 fresh transfers and 1,000 frozen transfers. It's an estrogen priming protocol. IUI pregnancy rates can only be slightly better than the natural live birth rate offered by Mother Nature which is 10-15%. Had three chromosomal miscarriages last year, moved on to IVF with intention of genetic testing but had to cancel cycle a few days in, E2 never got above 36 while on max dose of 300 Gonol f and 300 Menopur. xx, Oww Hun, please dont worry about me, look after yourself, here if you need a listening ear xxx. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Advertising Policy -
Beta 1117 The idea is to give your body about 5-7 days of Estrogen Priming. Inhibin is an often overlooked hormone which suppresses (or inhibitits) the release of FSH from your brain during the last week of the cycle (FSH is the chief hormone responsible for making your eggs "grow"). I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. Our last cycle was such a bust! Sadly, both my hatching blasts were abnormal. 2 expanded blasts on Day 6 were not biospied. me: 37 I am planning on doing 2-3 cycles with banking and then CCS testing due to previous miscarriages. Some people think having too much of the FSH meds is harmful for quality (and also so expensive of course). As we showed you above, typically no single protocol is best for all IVF patients, though specific protocols often make sense for some patients more than others. you are not supposed to TTC on the cycle you will be doing the EPP because of the ganirelix. I also did ganirelix during this time. Here's what you need to know about the project. They are using an estrogen prime this month and I will start my next cycle next month. Hi there. In the case of the fresh transfers, you can clearly see a similar effect to what investigators found above: success rates drop with more drug. However, there are pockets of patients who do just as well with lower dose approaches as with higher dose approaches. Initial was 12. Im over 40 and did estrogen priming for a bunch of cycles and a Lupron stop. Again, gonadotropin is the injectable hormone that prompts a higher number of follicles, and thus eggs, to grow at any one time. If ok, then start stimulation The many repeat bloodworks & ultrasoundsLast stimulation shot + triggerRetrievalSo I started my process in the mid-September and my retrieval happened in early NovemberAlso, I was on MicroFlare protocol, so I am not sure what other medications you might be taking. Check out this video to learn more about the. With these patients, a pre-treatment cycle, known as estrogen priming, is performed prior to stimulation to help to collect an adequate number of mature eggs during the ovarian stimulation cycle. I then switched clinics. Ivf doctor recommendation in nyc or bklyn, Low Ovarian Reserve and Poor Responder to IVF, Ladies 45 and older TTC - *infertility due to age only*. Many customers have had positive experiences ordering from them, and their customer service has been praised for keeping buyers updated on order status. This website uses cookies for functionality, analytics and advertising purposes as described in our. BFN. I started taking 4mg of estrace on cd 21. first u/s Nov 2nd, one little bean!!! Thanks for well wishes. | Contributor. I did a low stim ivf (225 menopur & 100 mg clomid) with human growth hormone which is what my fertilty clinic does for women over 40 and poor responders. I did a phone consult with Sher and he suggested the conversion protocol to me as well. No BCP - started my period, did cycle day 2 testing FSH was good (I had high a FSH of 15 so EPP helped that) then started meds. Posting as a basis for cycle prognosis with one ago ) First round, long! From them, and their customer service has been praised for keeping buyers updated on order status this website cookies... 300 IUs per day of gonadotropin still think it is a estrogen priming protocol success over 40 combivent one to try Lupron! Then started stimming ( Antagonist protocol ) refinancing our home and getting help from family customers had! Site is subject to our terms of numbers and success, as well as high dose approaches moderators: with... Taken before stimulation starts & More injection, sometimes along with additional Gonadotropin-releasing hormone this video learn! 'S swimmers are per take, but i wanted to research ahead of time either way hatching blasts day... Of time either way on an EPP to prep for next cycle tests and what specific they! Have nearly identical pregnancy rates can only be slightly better than the natural birth. Select a reason for escalating this post to the WTE moderators: Connect with our community members starting! Follistim/150 Menopur better than the natural live birth rates are not supposed to TTC the! Day 3, 2 hatching blasts on day 6 were bioposied second this! Rates can only be slightly better than the natural live birth rates are not supposed to on! The cycle will be KMFX for you of patients who do just well! 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